Microhepatic histoarchitecture and liver enzymes evaluation in female lactating Wistar rats treated with metoclopramide and some atypical antipsychotic drugs

Disruption of Orolingual Behavior in Rats Treated with Atypical Antipsychotic Drugs

Attentional and emotional functioning in schizophrenia patients treated with conventional and atypical antipsychotic drugs

BACKGROUND Effectiveness of antipsychotics in treating emotional and cognitive deficits in schizophrenia still remains controversial. The aim of our study was to assess emotional and cognitive functioning in schizophrenic inpatients currently treated with typical antipsychotics (perphenazine, perazine, fluphenazine, and haloperidol) and in another group of schizophrenic inpatients currently on ...

Update on typical and atypical antipsychotic drugs.

Antipsychotic drugs (APDs) are best classified as typical or atypical. The distinction is based solely on their ability to cause extrapyramidal side effects (EPS), including tardive dyskinesia (TD). The two classes differ in mechanism of action, with atypical APDs providing important modulation of serotonergic neurotransmission. TD increases the death rate and can be minimized by limiting use o...

Cognition, schizophrenia, and the atypical antipsychotic drugs.

The Cognitive Deficit in Schizophrenia Schizophrenia was originally called dementia praecox by Emil Kraepelin, the great 19th century psychiatric nosologist, who coined the term to categorize a group of young psychotic patients who went on to develop dementia. A decade later, Eugen Bleuler, noting that most patients who had similar psychotic and affective features did not become severely dement...

Neuroleptic malignant syndrome and atypical antipsychotic drugs.

OBJECTIVE The incidence of neuroleptic malignant syndrome (NMS) is not known, but the frequency of its occurrence with conventional antipsychotic agents has been reported to vary from 0.02% to 2.44%. DATA SOURCES MEDLINE search conducted in January 2003 and review of references within the retrieved articles. DATA SYNTHESIS Our MEDLINE research yielded 68 cases (21 females and 47 males) of N...